Woven design data transmission using TTL logic for 128 hooks electronic cardless jacquard

A new electronic cardless handloom weaving apparatus which is an alternate to mechanical jacquard has been developed in order to improve the productivity and to reduce the occupational stress of the handloom weaver. The main objective of this development is to retain the features of the handloom with comfortable weaving and reduced laborious work. This development is based on embedded system to control the warp yarn vertical movement. The conventional punched cards are replaced by multimedia memory card file system. The shedding effect is programmatically controlled through miniature stepper motors. The new apparatus is found to be highly versatile for introducing variety of weaving patterns

Effectiveness of Teaching Standardized Protocol on Safe Medication Administration Process Upon the Level of Knowledge among Nurses at a Tertiary Care Hospital, Chennai

Strategies to improve medication safety focused on acute care settings. Twenty-six studies and descriptions of quality improvement projects were identified. Strategies used to focus on recommendations to prevent medication errors at various stages, from a nationwide voluntary organization to improve safety of patients and empower education system of nurses and other health care providers in safe practices in health care system and vast growing technology

Medication Reconciliation

The Institute of Medicine (IOM) stated that preventable medication errors are the most common type of errors in healthcare. It is of fundamental significance when building a safer care continuum, as it highlights the reason for continuous and more vigilant medication reconciliation and required effort at all interfaces of care, including community. Without a robust medication reconciliation process, the potential for catastrophic outcomes remains a constant concern. Prevention of medication errors is essential through strategies that are based in evidence of medication reconciliation strategies on medication errors in community

Identification of nitrated proteins that may play a critical role in the pathogenesis of methotrexate induced small intestinal damage in the rat and possible ways to prevent the damage by the administration of nitric oxide synthase inhibitor

The ultimate purpose of the study was to identify the modifications and consequence due to nitrosative stress by which MTX causes small intestinal damage. Increased nitric oxide production was found to be associated with gut barrier failure and inflammation. In the first study, we have assessed the role the nitrosative stress in MTX induced small intestinal damage by measuring the nitrosative stress parameters in the small intestine samples at 24 hours after 3 consecutive intraperitoneal injections of MTX at the dose of 7 mg / kg body weight. Nitric oxide level (Nitrite + Nitrate), expression of inducible nitric oxide synthase and nitrotyrosine was increased in MTX treated samples. We also assessed peroxynitrite induced protein tyrosine nitration, subcellular distribution on nitrated proteins to identify the proteins that may undergo nitration. We found many proteins either increase or decrease expression of nitrotyrosine modification in the cell fractions including homogenate, nucleus, mitochondria, microsomes and cytosol. Thus, it is concluded that there is strong association of nitrosative stress that lead to nitration of proteins to the extent of major subcellular fractions may play a role in MTX induced mucositis. First study suggested the role of nitrotyrosine but not consequence of nitration in MTX induced small intestine damage. Nitrosative stress leads to modification in the activity and function of enzymes that are protein in nature. Therefore, the second study was designed to determine the alteration in the activity of enzymes that may undergo nitration. Therefore, we assessed the activity of enzymes those we speculate proteins from the first study mainly ETC complexes, TCA cycle and antioxidant enzymes. The ETC complex enzymes - cytochrome-c-oxidase and F1-ATPase enzyme activity was significantly decreased in MTX treated samples when compared to control. The TCA cycle enzymes - aconitase, succinate deydrogenase, creatine kinase and glutamate dehydrogenase were significantly decreased in MTX treated samples when compared to control. The antioxidant enzymes - catalase, glutathione peroxidase, glutathione-s-transferase, carbonic anhydrase enzyme activity was significantly decreased and superoxide was increased in MTX treated samples as compared to control. This result indicates that MTX alters the activity of the enzymes that are known to undergo nitration and inactivation. MTX induced loss of ETC complex activity and depletion of antioxidant enzymes may contribute to mitochondrial injury, enterocyte apoptosis, and small intestinal injury. Previous studies have shown that tyrosine nitration triggers dissociation of IκB from NuclearFactor-κB (NF-κB), which results in activation of this pathway that plays an important role in cancer and inflammation. Therefore, the third study was designed to assess the role of inflammatory signaling pathway in MTX induced small intestine damage. MTX treatment resulted in NFκB activation and nuclear translocation as evidenced by immunofluorescence, immunohistochemitry and immunoblot analysis of intestinal segments. We also found that there is significant increased expression of NFκB target proteins and genes including TNFα, COX2, iNOS, PLA2, MMP2, MMP9, HO1 and HSP70 in MTX treated samples as compared to control. These results concluded that there is activation of NFκB signaling inflammatory pathway in MTX treated small intestine samples. Studies have been shown that nitration of cytochrome-c leads to the release from mitochondria to cytosol and activates caspase cascade leading to activation of apoptosis pathway. Therefore, the fourth study was designed to assess the role of apoptotic signaling pathway in MTX induced small intestine damage. The expression of CYT-C was decreased in mitochondria and increased in cytosol fraction in MTX treated samples as compared to control. We also found significant increase in active caspases expression (CASP-9 and CASP-3), PARP expression and DNA fragmentation in the MTX treated small intestine samples as compared to control. Thus, it is concluded that there is activation of intrinsic apoptotic signaling pathway in MTX treated small intestine samples. Aminoguanidine, specific inhibitor of iNOS reduces the nitrosative stress induced damages. Thus, the last study was designed to investigate the protective effect of aminoguanidine in MTX induced small intestine damage. Rats were pretreated with two different concentrations (30mg and 50mg per kg body weight) of aminoguanidine one hour prior to MTX administration. There is improvement in the morphology of the damaged small intestine section in aminoguanidine pretreated group when compared to MTX treated group. Thus, aminoguanidine attenuated MTX induced small intestine damage by light microscopy. The nitrosative stress parameters like nitric oxide levels, expression of iNOS and NTY was decreased and the alteration in the activity of enzymes in MTX treated samples was reversed by aminoguanidine pretreatment. Thus, aminoguanidine abolished the increased nitrosative stress in response to MTX. AG pretreatment attenuated MTX induced upregulation of NFκB and its proinflammatory target genes protein expressions, iNOS, TNF, COX-2 and PLA2. AG pretreatment attenuated MTX induced mitochondrial apoptotic pathway, CYT-C, CASP-9, CASP-3, PARP cleavage, and DNA fragmentation. However, AG pretreatment had no significant effect on the mRNA expressions of these proteins. In conclusion, AG pretreatment improved MTX induced morphological changes in the small intestine inhibited the NFκB inflammatory pathway and apoptotic pathway. Thus, aminoguanidine has a protective role in MTX induced mucositis. Aminoguanidine has been administered in both physiological and pharmacological amounts to humans and animals, and there is widespread agreement that it is non-toxic even at higher concentration up to 500mg. It is therefore concluded that aminoguanidine appeared to be potential agent that reduce MTX induced small intestinal damage

Multimodal Classification of Urban Micro-Events

In this paper we seek methods to effectively detect urban micro-events. Urban micro-events are events which occur in cities, have limited geographical coverage and typically affect only a small group of citizens. Because of their scale these are difficult to identify in most data sources. However, by using citizen sensing to gather data, detecting them becomes feasible. The data gathered by citizen sensing is often multimodal and, as a consequence, the information required to detect urban micro-events is distributed over multiple modalities. This makes it essential to have a classifier capable of combining them. In this paper we explore several methods of creating such a classifier, including early, late, hybrid fusion and representation learning using multimodal graphs. We evaluate performance on a real world dataset obtained from a live citizen reporting system. We show that a multimodal approach yields higher performance than unimodal alternatives. Furthermore, we demonstrate that our hybrid combination of early and late fusion with multimodal embeddings performs best in classification of urban micro-events

Synaptic partner prediction from point annotations in insect brains

High-throughput electron microscopy allows recording of lar- ge stacks of neural tissue with sufficient resolution to extract the wiring diagram of the underlying neural network. Current efforts to automate this process focus mainly on the segmentation of neurons. However, in order to recover a wiring diagram, synaptic partners need to be identi- fied as well. This is especially challenging in insect brains like Drosophila melanogaster, where one presynaptic site is associated with multiple post- synaptic elements. Here we propose a 3D U-Net architecture to directly identify pairs of voxels that are pre- and postsynaptic to each other. To that end, we formulate the problem of synaptic partner identification as a classification problem on long-range edges between voxels to encode both the presence of a synaptic pair and its direction. This formulation allows us to directly learn from synaptic point annotations instead of more ex- pensive voxel-based synaptic cleft or vesicle annotations. We evaluate our method on the MICCAI 2016 CREMI challenge and improve over the current state of the art, producing 3% fewer errors than the next best method

Pengetahuan paramedik mengenai teknik triage di Unit Kecemasan, Hospital Universiti Sains Malaysia(HUSM), Kelantan

Latarbelakang : Unit Kecemasan merupakan fasiliti atau kemudahan perkhidmatan yang sibuk dengan pesakit yang beratur panjang dan tempoh masa menunggu yang lama dengan penyakit atau sakit yang major ataupun minor. Oleh itu, sistem triage diperkenalkan untuk menyelesaikan masalah terlalu ramai orang dan juga memberi rawatan segera kepada mereka mengikut prioriti serta dalam tempoh masa yang singkat (kes atau keadaan yang dialami oleh pesakit). Kajian telah menunjukkan bahawa seseorang pengawai triage perlu berpengetahuan dan berkebolehan serta mempunyai pengalaman yang cukup untuk mengendalikan teknik triage yang berkesan di Unit Kecemasan. (Hay eta/. 2001; Anonymous 2002; Ng eta/. 2002) Tujuan: Kajian ini bertujuan untuk menilai pengetahuan paramedik mengenai teknik triage di Unit kecemasan. Pengetahuan panting bagi setiap prosedur atau proses yang dilakukan terutama di kawasan kecemasan. Desain : Jenis kajian yang digunakan adalah deskriptif dan penilaian. Subjek : Sebanyak 30 subjek iaitu paramedik (jururawat sebanyak 24 dan pembantu perubatan sebanyak 6) dari Unit Kecemasan, Hospital Universiti Sains Malaysia (HUSM) telah dijadikan sebagai sampel dalam kajian ini. Kaedah : Borang soalselidik yang mengandungi 16 soalan dengan pilihan jawapan telah digunakan sebagai kaedah penilaian dalam kajian ini. Keputusan : Daripada kajian yang telah dijalankan, secara keseluruhan didapati jumlah paratus jawapan betul yang dapat dijawab oleh staf adalah sebanyak 49.5% manakala peratus yang diperolehi bagi jawapan yang salah adalah 50.5% yang telah melebihi jawapan betul. Dapat disimpulkan bahawa staf masih kekuranga

An efficient grid scheduling algorithm with fault tolerance and user satisfaction

Problem Statement. The advances in human civilization lead to more complications in problem solving. Grid computing serves as an efficient technology in solving those complicated problems. In computational grids, the grid scheduler schedules the task and finds the appropriate resource for each task. The scheduler must consider several factors such as user demand, communication time, failure handling mechanisms, and reduced makespan. Most of the existing algorithms do not consider user satisfaction. Thus a scheduling algorithm that handles failure of resources and achieves user satisfaction gains more importance. Approach. A new bicriteria scheduling algorithm (BSA) that considers user satisfaction along with fault tolerance has been introduced. The main contribution of this paper includes achieving user satisfaction along with fault tolerance and minimizing the makespan of jobs. Results. The performance of this proposed algorithm is evaluated using GridSim based on makespan and number of jobs completed successfully within user deadline. Conclusions/Recommendations. The proposed BSA algorithm achieves reduced makespan and better hit rate with higher user satisfaction and fault tolerance

Methods for Detecting and Quantifying Viable Bacterial Endo-Spores

Methods and systems for detecting viable bacterial endospores in a sample and related methods to quantify viable bacterial endospores in a sample

Current Treatment of Venous Thromboembolism

Venous thromboembolism (VTE), comprising deep vein thrombosis and pulmonary embolism, is a common disorder with at least 250,000 new events occurring each year in the United States alone. Treatment of VTE entails anticoagulation, which is achieved initially with the use of a parenterally administered anticoagulant followed by a more prolonged course of treatment with an oral vitamin K antagonist. The duration of anticoagulation depends on the clinical assessment of the benefit-risk ratio of prolonged anticoagulation versus the risk of recurrent events. In this review, we discuss some of the issues that we believe are among the most critical unanswered questions in the management of VTE in the present era